What is autism spectrum disorder?
Autism spectrum disorder (ASD) is a neurodevelopmental disorder characterized by impairment in social communication and interaction, and restricted and repetitive behavior and activities. By definition, this disorder exists on a spectrum of severity with great variance between affected individuals. The prevalence of ASD is 1% and is roughly four times more common in men than women.
The current diagnosis of autism spectrum disorder now encompasses previous, outdated diagnoses related to autism: early infantile autism, childhood autism, Kanner's autism, high0functioning autism, atypical autism, pervasive developmental disorder not otherwise specified, childhood integrative disorder, and Asperger's disorder.
What does ASD look like?
Risk Factors
- Highly heritable
- Roughly 15% of cases may be associated with de novo genetic mutation
- Advanced parental age
- Low birth weight
- Fetal exposure to valproate
Prognosis
- Lack of social and communication abilities may impact learning
- Some adults may have difficulty establishing independence
- Many individuals may have difficulty living independently and obtaining employment
Differential Diagnosis
- Rett syndrome
- Selective mutism
- Language disorders
- Social (pragmatic) communication disorder
- Attention-deficit/hyperactivity disorder
- Intellectual disability
- Stereotypic movement disorder
- Schizophrenia
How is ASD investigated?
- Genome-wide microarray analysis
- Fragile X syndrome testing and sequencing of PTEN gene for individuals with a large head circumference
- Screening tools:
- Autism Spectrum Quotient (AQ) (Adult, Adolescent, and Child versions)
- Quantitative Checklist for Autism in Toddlers (Q-CHAT)
- Modified Checklist for Autism in Toddlers, Revised (M-CHAT-R)
How is ASD treated?
- Applied behavioral analysis (ABA)
References
[1] American Psychiatric Association. (2013). Diagnostic and Statistical Manual of Mental Disorders (5th ed.). Arlington, VA.
[2] Boyd, M. A. (2019). Psychiatric & mental health nursing for Canadian practice. Wolters Kluwer.
[3] Townsend, M. C. (2015). Psychiatric mental health nursing. F.A. Davis.